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Brian Bloom: Hockey Sticks and Cheerleaders Do Not Go Together

Home or away, Brian Bloom is recognized for his wildly successful conference and boutique investment bank.

With a mission to uncover and cultivate Canadian life sciences companies through scientific focus and range of services, Bloom Burton & Co., which he co-founded in 2008, has risen swiftly to be profitable and globally unique.

And its Bloom Burton Healthcare Investor Conference achieved actual hockey stick growth since it broke onto the Canadian biotech scene 5 years ago.

But hockey and cheerleaders do not go together. Brian’s knowledge of the Canadian biotech scene, and his seat on umpteen boards, leads him to a frank, no-apologies stance on the industry.

 

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Kate Bingham, a Voice of Reason from the UK

Brexit isn’t the only newsworthy and dismal problem out there. Consider a couple of others – some VCs would rather not touch them with a ten foot pole, yet Kate Bingham is taking a stab at them:

There’s Alzheimers. This past October, SV Life Sciences where she is Managing Partner, became the fund manager of the Dementia Discovery Fund. Launched with a charity and six pharmas at the table, and $100M in the bank, the fund brings a fresh operating model to the tired approach.

And then there’s gender diversity. Following the JP Morgan biotech investors conference this year, Kate co-authored an open letter to the industry, alongside Karen Bernstein of Biocentury. It queried why “the smart, dynamic women in our industry are forced to choose between demeaning themselves and making business connections.”

Kate has the knack for looking at improbable problems and seeing a path to success. Perhaps because she herself is an improbability in the industry – having found her way into it 25 years ago, on account of a lucky phonecall and a mistaken post-it note. She joins me on this episode to talk closed deals and open letters.

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Sven Jacobson Doesn’t Have a Swelled Head

Have you heard the one about the guy who founded a biotech startup in the middle of Manhattan? Around a repurposed, hydrolysable, insoluble small molecule? To treat massive strokes, traumatic brain injury, and other neuro indications? Using a highly translatable rodent model? During the financial crisis? Unpartnered? And who spent $1M per year to generate randomized, placebo-controlled, double-blind PhII results that show a 50% reduction in mortality from strokes that were too big for other trials and too late for other treatments?

That’s Sven Jacobson. He is CEO of Remedy Pharmaceuticals, and was Partner at Carrot Capital Healthcare Ventures, the nontraditional VC that founded and funded Remedy.

For a long time, Remedy was one guy and one drug. But that drug, Cirara™, combats swelling in the central nervous system – a root cause of morbidity and mortality in multiple diseases. Today Cirara™ is still investigational, but in line to be the first therapeutic advance in the stroke field in over 20 years. And an in-progress Ph II trial in TBI has it poised to tackle football as well.

Sven doesn’t have a swelled head – and he doesn’t want anyone else to have one either.

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Colin Cahill’s Venrock Diagram

Colin Cahill swears he didn’t grow up wanting to be a life science venture capitalist. But you would think he had planned it from his very first job cleaning glassware. His path from there to Venrock may appear linear after the fact, but at the time it was based on serendipity plus a hunch he should stay close to both science and business for as long as possible.

In this episode, Colin deconstructs some of the great VC mysteries:

How do they decide which deals to do, since “there’s no rules-based decision paradigm for venture investing”?

Why, when other VCs have run screaming from med devices, has Venrock retained its breadth?

And what does “falling in love” mean when a venture capitalist says it?

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Greg Verdine will not take “undruggable” for an answer

Greg Verdine has evolved from merely being a Harvard prof, to consulting for big pharma, to starting biotech companies, to being a Venture Partner, and even to co-founding a non-profit institute – not just sequentially, but largely in parallel.

He has teamed up with Third Rock Ventures, TPG Biotech, AppleTree Partners, and he unveils his brand new gig with WuXi Ventures.

Greg co-founded the biotechs Enanta (ENTA), Tokai (TKAI), Gloucester (now Celgene), Aileron, Warp Drive, WaVe (WVE), and Fog. His day job today, if forced to list just one, is CSO of Warp Drive Bio. He reveals a couple of secrets about Warp Drive strategy and lifts the fog off of Fog Pharma, his latest – and still stealth – newco.

As different as these companies are, a common theme runs through them: to cure the incurable by drugging the undruggable.  With apologies to Star Trek, that is Greg’s personal mission: to boldly go where no drug has gone before.

In fact Greg wants to blow up the conventional meaning for the word “drug”. He sees beyond the pharma industry’s small molecules plus the biotech industry’s biologics, because they seem positively “puny” in the context of human biology. And he has clever tricks and other modalities at his disposal – not to mention the blueprints: 135,000 bacterial genomes, where the answers cannot hide.

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The Multivalent Mathai Mammen

In the late nineties, a company named “Advanced Medicine” came together with the 4Cs of entrepreneurship in place: a concept, co-founders, capital, and some well-placed cold-calls. Mathai Mammen was one of those co-founders, still living in a dorm at the time. The company’s investors evolved, it renamed itself, went public, and ultimately split into two independent companies: Innoviva (INVA) and Theravance Biopharma (TBPH).

Today, Mathai is the SVP of R&D at Theravance Biopharma. Under his leadership, they have always done things a little differently. In the beginning they used their seed capital to build an in-house vivarium. They have discovered all of their development candidates – 31 and counting – internally or collaboratively. And after 3 approvals, they left their royalty stream to Innoviva and struck out on their own to focus on R&D – because “it’s difficult to be innovative when you’re in the shadows.”

Mathai has had a longstanding reputation as one of the good guys in the industry, but in recent years he has doubled down. After two extraordinary family tragedies, he calls out the importance of persistence, humility, and empathy above all – both in and outside of business.

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Ron Cohen: Founder & Confounder (Part 1)

Ron Cohen has defied Venture Capital wisdom by founding Acorda Therapeutics over 20 years ago and remaining the CEO to this day.  Originally hearing “no” from 70 VCs, he nevertheless grew the company into a public biotech worth nearly $2B today.  As unlikely as that has been, there would’ve been no Acorda had he found more success on Broadway.

Ron discusses his road from Jeopardy! champion to entrepreneur, the role played by his flat head and great hair, and what on earth could motivate someone to invest in drug development. He also explains how upstate NY does not start at 96th St.

The two-part interview continues in the following episode, Part 2.

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Ron Cohen: Founder & Confounder (Part 2)

This past year, Ron took over the role of Chair of BIO, the Biotechnology Innovation Organization. From that vantage point, he comments on the high drama in 2015 that has entertained – and sometimes threatened – the industry. He discusses inter partes review, the right and wrong conversations on drug pricing, and the choices that determine the pace of R&D within our ecosystem of brilliant science and entrepreneurship. He also projects some hot trends and throws down the gauntlet for biotech in NY. If you listen carefully, you can hear him pounding the table.

This episode, Part 2 of the two-part interview, picks up where Part 1 left off, on the subject of social media’s role in biotech.

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